STUDY OF THE ALTERNATIVE ISOFORMS OF PRDM16 PROTEIN AND OF THEIR POSSIBLE ROLE IN LEUKEMOGENESIS
PRDM16 is a member of PRDM gene family, composed of 17 genes. All the PRDM genes so far connected to cancer have (at least) two isoforms, which differ by the presence (PR+) or absence (PR-) of the PR domain that is related to SET domain of histone lysine methyltransferases (HKMTases). In cancer cell...
Università degli Studi di Milano