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Functional study of regulatory elements in CDK5R1 3’-UTR: evidence on post-transcriptional gene expression regulation

Background CDK5R1 encodes for p35, a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), whose activity plays a central role in neuronal migration during central nervous system development. Cdk5r KO mice have severe cortical lamination defects and suffer from adult mortality and seizures...

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Main Author: MONCINI
Other Authors: SILVIA
Format: Doctoral Thesis
Language: English
Published: Università degli Studi di Milano 2007
Online Access: http://hdl.handle.net/2434/200505 Restricted access